Title: Chemical Pharmacology of Protein Conjugates and Natural Products
Speaker: Prof. Gonçalo Bernardes, Department of Chemistry, University of Cambridge
Time: 11.00, 5 April, 2016
Location: 408/Building 24
Chemical Pharmacology of Protein Conjugates and Natural Products
Gonçalo J. L. Bernardes
University of Cambridge, Department of Chemistry, Lensfield Road, Cambridge CB2 1EW, UK, firstname.lastname@example.org
Instituto de Medicina Molecular, Faculdade de Medicina da Universidade de Lisboa, Av. Prof. Egas Moniz, 1649-028 Lisboa, Portugal, email@example.com
Our work centers on reaction engineering for site-selective chemical protein modification and its use to provide insight into biology and for the development of protein therapeutics.1 This lecture will cover recent examples of emerging areas in our group in: (i) site-selective chemical modification of proteins at cysteine and lysine, (ii) bioorthogonal labeling of collagen in live cells, (iii) a new method for histidine-metallation of proteins with a [Ru(CO)2]2+ fragment that yields artificial metalloproteins that are able to deliver CO in vivo in a controlled manner, (iv) CO-mediated immunomodulation for cancer therapy, and (v) the exploitation of natural product scaffolds for targeting of calcium channels overexpressed in cancer cells.
(1) Krall, N.; da Cruz, F.P.; Boutureira, O.; Bernardes, G.J.L. Nat. Chem. 2016, 8, 103.