Topic: Understanding and designing life from the structure of biomolecules
Speaker: Dr. ZHANG Changsheng
Time: Place: Meeting room 408, Building 24
Organizer: School of Pharmaceutical Science and Technology, Tianjin University
Brief introduction of Speaker:
Dr. Zhang got his bachelor degree for chemical engineering and minor in computer science in Harbin Institute of Technology. Then, he chose computational chemistry and computational biology as his PhD research in Peking University. He developed methods for protein-protein docking and computational protein engineering. After that he focus his work on functional protein design in his postdoctoral research in Peking-Tsinghua center for life sciences. A protein was engineered to bind uranyl selectively and with femtomolar affinity and published on Nature Chemistry. New methods were developed for peptide drug design. Helical peptides were computational designed for targeting TNF alpha and published on Angewandte Chemie-International Edition. In his second postdoctoral work, he developed AMOEBA polarizable force field for nucleic acid. Polarization is considered as the most important feature of the next generation molecular force fields, which aim more accurate biomolecular simulation and drug design.