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关于邀请南安普顿大学Philip A.Gale教授来中心作报告的通知

发布时间:2015-09-17    来源:

各位老师: 
  您好,南安普顿大学Philip A.Gale教授于2015年9月25日上午10:00在南开大学元素所合成楼学术报告厅做学术报告,欢迎感兴趣老师和同学参加。

具体信息如下: 


报告题目:Advances in anion and amino acid transport 
报告人:
Prof.Philip A.Gale (Editorial Board Chair, Chemical Society Reviews) 
      University of Southampton, UK 
报告时间:2015年9月25日(星期五)上午10:00 
报告地点:南开大学元素所合成楼学术报告厅 
报告摘要: 
Diseases or “channelopathies”, such as cystic fibrosis, are caused by mis-regulation of anion transport across epithelial cell membranes. A number of research groups including our own are developing synthetic compounds to mediate anion and hence replace the functionality of the faulty anion channels. Additionally disruption of chemical potentials within cells can lead to apoptosis hence such compounds may have anti-cancer activity. 

By studying structurally simple systems and varying their properties to change the degree of preorganisation, affinity for anions or lipophilicity we have begun to rationalize why particular anion transport mechanisms (co-transport or antiport processes) occur in particular cases.  
In this lecture our latest results will be presented including the use of QSAR techniques to rationalise the design of new transporters, the development of new transport assays, the influence of intramolecular hydrogen bonding on transport efficiency and the effect of anions transporters on cells. Our latest work on amino-acid transport will also be presented. 

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